Design, Synthesis, Fungicidal Activity, and Molecular Docking Study of 2-Aminothiazole Derivatives

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In order to obtain amide compounds with enhanced antifungal activity, twelve 2-aminothiazole derivatives were synthesized using combinatorial chemistry techniques. The newly synthesized compounds were characterized by using various techniques such as 1H NMR, 13C NMR, ESI-MS, and elemental analysis. Notably, compound 11b not only exhibited a high inhibitory rate against Sclerotinia sclerotiorum but also possessed certain anticancer effects. Molecular docking analysis provided a scientific basis for how this compound achieves its antifungal effects.