Key result
Influenza NS2 C-terminal residues 81-100 prove essential for M1 binding and progeny vRNP nuclear export.
Why the study?
The significance of the association between influenza virus NS2 and M1 for the nuclear export of viral ribonucleoproteins is still poorly understood.
Population
Influenza virus model
Comparison
Presence vs absence of NS2 C-terminal domain (residues 81-100)
Design
Preclinical experimental study
Authors
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May guide NS2-targeted antiviral design; leaves open clinical translation from this animal data.
The C-terminal domain of the influenza virus NS2 protein is essential for M1 binding and nuclear export of vRNPs.
Shimizu et al. (2010) studied Influenza virus infection. C-terminal domain of NS2 (residues 81-100) was evaluated on M1 binding and nuclear export of progeny vRNPs. The C-terminal domain of the influenza virus NS2 protein (residues 81-100) is essential for M1 binding and the nuclear export of progeny viral ribonucleoproteins.
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