Key result
Oxidized LDL upregulates CD36 alternative first exons up to ~6-fold in THP-1 macrophages.
Why the study?
The molecular mechanisms regulating tissue-specific expression of the CD36 gene and its alternative first exons are not yet fully understood.
Population
Human tissues including skeletal muscle, heart, liver, adipose tissue, placenta, spinal cord, cerebrum, and monocytes
Comparison
Expression of alternative first exons of CD36 with and without oxidized low density lipoproteins in THP-1 macrophages
Design
Molecular expression analysis study
Authors
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Highlights CD36 promoter regulation in atherogenic macrophages; leaves open in vivo relevance and clinical translation.
The complex, tissue-specific regulation of CD36 alternative promoters highlights its multifunctional role in cellular processes including lipid transport and atherosclerosis.
Andersen et al. (2006) studied this question. Oxidized low density lipoprotein (oxLDL) vs. Normal LDL or untreated cells was evaluated on Expression levels of alternative first exons of CD36. All alternative first exons of the CD36 gene were upregulated 3-fold to 6-fold in THP-1 macrophages in response to oxidized low density lipoproteins.
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