Key result
Abnormal glucose tolerance is linked to a ~60% higher prevalence of multivessel CAD.
Why the study?
The relationship between glucose tolerance status and severity of coronary artery disease in patients with coronary ischemia was unclear.
Is abnormal glucose tolerance associated with increased severity of coronary artery disease in patients with coronary ischemia?
Observational (n=235)
Is abnormal glucose tolerance associated with increased severity of coronary artery disease in patients with coronary ischemia?
Absolute Event Rate: 69% vs 43%
p-value: p=0.002
Abnormal glucose tolerance, including impaired glucose tolerance, is associated with increased angiographic severity of coronary artery disease.
Abnormal glucose tolerance signals higher CAD burden on angiography; leaves open whether glucose-targeted interventions improve outcomes in ischemic patients.
Consecutive patients (n = 235) with coronary ischemia were studied; 69 patients (29%) had diabetes. An oral glucose tolerance test (OGTT) was administered to the 166 patients without diabetes; 76 (46%) had normal glucose tolerance (group I = NGT), 68 (41%) had impaired glucose tolerance ([IGT] group II = IGT), and 22 (13%) had diabetic glucose tolerance (DGT). The DGT patients were added to the known diabetics forming (Group III; n = 91). Multivessel disease was significantly more prevalent in group III; 30 patients (43%) in group I, 32 patients (51%) in group II, and 57 patients (69%) in group III (P = .002). Gensini scores were 43.20 ± 24.92 in group I, 54.22 ± 42.61 in group II, and 60.59 ± 38.21 in group III. (P = .037) The severity of coronary artery disease is related to abnormal glucose tolerance. Patients with IGT could be neglected in terms of interventions focused to improve risk factors.
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Nurkalem et al. (2010) conducted an observational in Coronary ischemia (n=235). Abnormal glucose tolerance vs. Normal glucose tolerance was evaluated on Multivessel disease (p=0.002). Abnormal glucose tolerance was associated with more severe coronary artery disease, with multivessel disease in 69% of diabetics vs 43% of those with normal glucose tolerance (P=0.002).
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