May 1, 2005Angiology
Increased Fasting Plasma Insulin Concentrations are Associated with the Severity of Angiographic Coronary Artery Disease
Key result
Higher fasting plasma insulin linked to greater angiographic CAD severity in obese patients.
- P<0.0001
- n=82
Why the study?
The association between fasting plasma insulin concentrations and the severity of angiographic coronary artery disease in obese patients was unclear.
Are increased fasting plasma insulin concentrations associated with the severity of angiographic coronary artery disease in overweight patients with suspected symptomatic CAD?
Population
82 patients with BMI >25 kg/m2 undergoing coronary angiography for suspected symptomatic CAD
Comparison
Increased fasting plasma insulin concentrations vs lower insulin concentrations
Design
Cross-sectional study
Authors
Discussion
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Member takes
Implication
Fasting insulin levels showed no link to CAD extent in overweight patients; leaves open any prognostic role in symptomatic disease.
Study Design
Type
Cross-Sectional (n=82)
Structured PICO
Are increased fasting plasma insulin concentrations associated with the severity of angiographic coronary artery disease in overweight patients with suspected symptomatic CAD?
P
Population
82 obese patients (mean age 60 years, 38% female) undergoing coronary angiography for suspected symptomatic CAD.
E
Exposure
Increased fasting plasma insulin concentrations (exposure)
O
Outcome
Severity of angiographic coronary artery disease (categorized as left main or 3-vessel, 2-vessel, 1-vessel, or no obstructive CAD)surrogate
Main Result
p-value: p=<0.0001
Increased fasting plasma insulin is an independent risk factor for more severe angiographic coronary artery disease in overweight and obese patients.
Cite This Study
Sukhija et al. (2005) conducted a cross-sectional in Suspected symptomatic coronary artery disease (CAD) (n=82). Increased fasting plasma insulin concentrations was evaluated on Severity of angiographic CAD (p=<0.0001). Increased fasting plasma insulin concentrations were identified as a significant independent risk factor for the severity of angiographic CAD in obese subjects (p < 0.0001).