Key result
Family history of IHD linked to ~127% higher prevalence of significant CAD.
Why the study?
The relationship between family history of ischaemic heart disease and the presence of coronary artery disease was unclear in patients undergoing coronary arteriography prior to valve replacement.
Does a family history of ischaemic heart disease predict the presence of significant coronary artery disease in patients undergoing coronary arteriography prior to valve replacement?
Population
387 patients undergoing routine coronary arteriography prior to valve replacement
Comparison
Family history of ischaemic heart disease vs no family history
Design
Observational study
Authors
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Family history of ischaemic heart disease is an independent predictor of significant coronary artery disease in patients undergoing evaluation prior to valve replacement.
Observational (n=387)
Does a family history of ischaemic heart disease predict the presence of significant coronary artery disease in patients undergoing coronary arteriography prior to valve replacement?
Absolute Event Rate: 48.6% vs 21.4%
p-value: p=<0.001
Family history of ischaemic heart disease is an independent predictor of significant coronary artery disease in patients undergoing evaluation prior to valve replacement.
Grech et al. (1992) conducted an observational in Patients undergoing routine coronary arteriography prior to valve replacement (n=387). Family history of ischaemic heart disease vs. No family history of ischaemic heart disease was evaluated on Presence of significant coronary artery disease (p=<0.001). A family history of ischaemic heart disease was associated with a significantly higher prevalence of significant coronary artery disease compared to no family history (48.6% vs 21.4%, P<0.001).
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