Key result
Bottom quartile HRR after pediatric heart transplant linked to ~600% higher death or re-transplantation risk.
Why the study?
The prognostic value of heart rate recovery after peak exercise in pediatric heart transplant recipients was not established.
Does impaired heart rate recovery after peak exercise predict death or re-heart transplantation in pediatric heart transplant recipients?
Cohort (n=128)
Does impaired heart rate recovery after peak exercise predict death or re-heart transplantation in pediatric heart transplant recipients?
Hazard Ratio: 7
Absolute Event Rate: 71% vs 16%
p-value: p=0.0013
A late decline in heart rate recovery Z score after pediatric heart transplantation is strongly associated with an increased risk of death or re-transplantation.
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Late HRR decline after ~6 years post-pediatric HTx was associated with higher death/retransplant risk; leaves open whether serial monitoring improves outcomes.
Giardini et al. (2013) conducted a cohort in Pediatric heart transplantation (n=128). Lowest quartile of heart rate recovery (HRR) Z score vs. Higher quartiles of HRR Z score was evaluated on Death or re-heart transplantation (HR 7.0, p=0.0013). Being in the lowest quartile of heart rate recovery Z score after pediatric heart transplantation was associated with a significantly higher risk of death or re-transplantation (HR 7.0; P=0.0013).
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