Key result
Baroreflex targeting emerges as a novel CVD therapy requiring long-term safety and efficacy studies.
Why the study?
Targeting the baroreflex system has emerged as a novel pathway to manage cardiovascular diseases, but studies examining the long-term safety and efficacy of such interventions in various cardiovascular diseases are needed.
Targeting the baroreflex system via invasive and noninvasive approaches has emerged as a novel pathway to manage cardiovascular diseases, though long-term safety and efficacy studies are needed.
Baroreflex dysfunction may represent a modifiable HF target; level 5 novel finding leaves open need for prospective trials before practice change.
The baroreflex system is involved in modulating several physiological functions of the cardiovascular system and can modulate cardiac output, blood pressure, and cardiac electrophysiology directly and indirectly. In addition, it is involved in regulating neurohormonal pathways involved in the cardiovascular function, such as the renin-angiotensin-aldosterone system and vasopressin release. Baroreflex dysfunction is characterized by sympathetic overactivation and parasympathetic withdrawal and is associated with several cardiovascular diseases, such as hypertension, heart failure, and coronary artery disease. Targeting the baroreflex system via invasive (eg, baroreflex activation therapy and endovascular baroreceptor amplification) and noninvasive approaches (eg, slow breathing exercises and exercise training) has emerged as a novel pathway to manage cardiovascular diseases. Studies examining the long-term safety and efficacy of such interventions in various cardiovascular diseases are needed.
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Salah et al. (2024) conducted a review in Cardiovascular disease. Baroreflex system targeting was evaluated. Targeting the baroreflex system via invasive and noninvasive approaches has emerged as a novel pathway to manage cardiovascular diseases, though long-term safety and efficacy studies are needed.
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