Key result
Elevated baseline A-FABP linked to ~57% greater risk of incident CVD.
Why the study?
Obesity-related adipokines may contribute to cardiovascular disease pathogenesis, but the independent predictive value of adipocyte-fatty acid binding protein and adiponectin for CVD risk is unclear.
Does elevated circulating adipocyte-fatty acid binding protein (A-FABP) predict incident cardiovascular events in a community-based cohort without previous CVD?
Population
1847 Chinese subjects without previous CVD from the Hong Kong CRISPS 2 cohort
Comparison
Elevated baseline serum A-FABP levels above optimal cutoff vs below cutoff
Design
Prospective community-based cohort study
Follow-up
Median 9.4 years
Authors
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Does not support routine A-FABP measurement; leaves open its incremental value beyond traditional factors in prospective cohorts.
Cohort (n=1,847)
Does elevated circulating adipocyte-fatty acid binding protein (A-FABP) predict incident cardiovascular events in a community-based cohort without previous CVD?
Hazard Ratio: 1.57 (95% CI 1.14–2.16)
p-value: p=0.006
Elevated baseline circulating A-FABP levels independently predict the development of incident cardiovascular events in a Chinese community-based cohort, improving risk reclassification beyond traditional risk factors.
Chow et al. (2013) conducted a cohort in Cardiovascular disease (n=1,847). Elevated adipocyte-fatty acid binding protein (A-FABP) levels vs. Levels below the optimal cutoff was evaluated on Incident cardiovascular disease (HR 1.57, 95% CI 1.14-2.16, p=0.006). Elevated baseline levels of adipocyte-fatty acid binding protein (A-FABP) predicted incident cardiovascular disease (HR 1.57; 95% CI 1.14-2.16; P=0.006) after adjusting for traditional risk factors.
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