Key result
Adhesive platelets increase clot contraction while fibrinogen reduces it, unaffected by proteolytic agents.
Why the study?
The mechanisms underlying plasma clot contraction and the roles of adhesive platelets, fibrinogen concentration, and proteolytic agents were not fully understood.
Clot contraction depends on the number of adhesive platelets and fibrinogen concentration, but not on proteolysis.
Answers are grounded in this paper and cite their sources.
Animal findings on clot contraction should not change practice; hypothesis-generating for platelet-fibrinogen interactions in thrombosis.
Abstract 1. Clot contraction was found to be associated with the action of whole, adhesive platelets. It was proportional to the number of adhesive platelets and not to the total number of platelets. It was inversely proportional to the fibrinogen concentration and a direct relationship was shown between the fibrinogen concentration and the number of platelets necessary to promote any fixed level of clot contraction. 2. Clot contraction could not be promoted solely by proteolytic agents and no association could be traced between clot contraction and proteolysis. 3. These findings are discussed with reference to the views concerning the mechanism of clot contraction.
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BESSIE M. STILL (1952) studied Plasma Clot Contraction. Adhesive platelets and fibrinogen concentration was evaluated on Clot contraction. Clot contraction was proportional to the number of adhesive platelets, inversely proportional to fibrinogen concentration, and not promoted by proteolytic agents.
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