Key result
Aging, metabolic syndrome, and CRP are linked to greater carotid intima-media thickness.
Why the study?
Metabolic syndrome is associated with increased cerebro- and cardiovascular disease risk, but prediction of carotid atherosclerosis by its components, serum C-reactive protein, and aging in Japanese inhabitants was not established.
Are aging, metabolic syndrome components, and serum C-reactive protein associated with increased carotid intima-media thickness in Japanese inhabitants?
Observational (n=887)
Are aging, metabolic syndrome components, and serum C-reactive protein associated with increased carotid intima-media thickness in Japanese inhabitants?
Aging, metabolic syndrome components, and elevated C-reactive protein are independent predictors of early carotid atherosclerosis in a Japanese population.
Answers are grounded in this paper and cite their sources.
May support MetS components and CRP for carotid risk stratification in aging Japanese men; leaves open prospective validation before practice change.
OBJECTIVE: metabolic syndrome (MetS) is known to be associated with an increased risk for cerebro- as well as cardio-vascular disease. Prediction of carotid atherosclerosis by components of MetS, serum C-reactive protein, aging and related factors was conducted for Japanese inhabitants. METHODS: A total of 887 subjects (761 males, 126 females) were included in the present study. Early atherosclerosis was assessed by measurement of the intima-media thickness of the common carotid arteries. RESULTS: The carotid arterial intima-media thickness on both the right and left sides significantly increased as the number of components of MetS increased. The maximum intima-media thickness values in the right (left) carotid arteries in the male and female subjects who fulfilled the criteria for MetS were 0.65 ± 0.18 (0.66 ± 0.17) mm and 0.58 ± 0.12 (0.59 ± 0.11) mm, respectively. After adjustment for several factors, the intima-media thickness related significantly with aging, some components of MetS and serum C-reactive protein by multiple regression analysis. β-coefficient of age was largest, presenting 0.457 in right side and 0.479 in left side. CONCLUSIONS: Aging, metabolic components and serum C-reactive protein are independent predictors of intima-media thickness in subjects.
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Kawada et al. (2011) conducted an observational in Carotid atherosclerosis (n=887). Aging, metabolic syndrome components, and serum C-reactive protein was evaluated on Carotid arterial intima-media thickness (β-coefficient for age 0.457 (right) and 0.479 (left)). Aging, metabolic syndrome components, and serum C-reactive protein were independent predictors of increased carotid intima-media thickness, with age having the largest effect (β=0.457-0.479).
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