Key result
Highest serum retinol and α-tocopherol linked to ~135% greater MetS risk versus lowest levels.
Why the study?
The study aimed to evaluate the association between serum retinol and α-tocopherol levels and metabolic syndrome in the Korean general population.
Are higher serum retinol and α-tocopherol levels associated with an increased risk of metabolic syndrome in the general population?
Cross-Sectional (n=5,885)
Are higher serum retinol and α-tocopherol levels associated with an increased risk of metabolic syndrome in the general population?
Odds Ratio: 2.351 (95% CI 1.748–3.163)
p-value: p=< 0.001
Higher serum levels of retinol and α-tocopherol are dose-dependently associated with an increased prevalence of metabolic syndrome and its components.
May warrant caution on retinol/α-tocopherol supplementation; leaves open causality in metabolic syndrome.
This study aimed to evaluate the association between serum retinol and α-tocopherol levels and metabolic syndrome (MetS) using data from the Korea National Health and Nutrition Examination Survey. Of the 24,269 individuals, 5885 adults (2672 men and 3213 women) were included. The prevalence of MetS and its components according to quartiles of serum retinol and α-tocopherol levels was calculated. Multivariate linear regression model was used to calculate the number of metabolic components according to serum vitamin levels. The association between serum vitamin levels and MetS with its components was assessed using multivariate logistic regression model. The prevalence of MetS was highest in Q4 and lowest in Q1 for both vitamins, regardless of sex. A dose-dependent association between serum retinol and α-tocopherol levels and MetS was observed. After adjustment for covariates, the odds ratio (OR) for MetS in Q4 compared to Q1 was 2.351 (95% CI: 1.748–3.163, Ptrend < 0.001) in the retinol group and 2.559 (95% CI: 1.953–3.353, Ptrend < 0.001) in α-tocopherol group. Among metabolic components, hypertriglyceridemia, high fasting glucose, and high blood pressure was positively associated with serum retinol and α-tocopherol levels. In conclusion, high serum retinol and α-tocopherol levels were associated with increased risk of MetS.
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Kim et al. (2020) conducted a cross-sectional in Metabolic syndrome (n=5,885). High serum retinol and α-tocopherol levels vs. Lowest quartile (Q1) levels was evaluated on Metabolic syndrome (MetS) (OR 2.351, 95% CI 1.748-3.163, p=< 0.001). Highest quartiles of serum retinol and α-tocopherol were associated with increased risk of metabolic syndrome compared to lowest quartiles (OR 2.351 and OR 2.559, respectively; Ptrend<0.001).
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