Key result
Endogenous PVN angiotensin II regulates arterial pressure toward normal during hemorrhagic hypotension in rats.
Why the study?
The role of endogenous angiotensin II in the paraventricular nucleus in regulating arterial pressure during hypotension was not established.
Does endogenous angiotensin II in the paraventricular nucleus regulate arterial pressure during hypotension in rats?
Does endogenous angiotensin II in the paraventricular nucleus regulate arterial pressure during hypotension in rats?
Endogenous angiotensin II in the paraventricular nucleus plays a major regulatory role in returning arterial pressure toward normal during hypovolemic hypotension in rats.
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Does not inform human hypotension management; extends preclinical evidence for brain renin-angiotensin system in rodents.
Khanmoradi et al. (2016) studied Hypovolemic-hypotension. Angiotensin II and AT2 antagonist (PD123319) microinjection was evaluated on Arterial pressure regulation and single-unit activity of PVN neurons. In a rat model of hemorrhagic hypotension, endogenous angiotensin II in the paraventricular nucleus regulated arterial pressure toward normal, confirming the brain renin-angiotensin system's role.
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