Key result
Angiotensin II and III microinfusion elevates rat BP, HR, and drinking, blocked by sarthran.
Why the study?
The role of angiotensin II and III in producing increases in blood pressure and drinking via the paraventricular nucleus of the hypothalamus was investigated to understand central mechanisms of body water homeostasis and blood pressure regulation.
Does microinfusion of ANG II and III into the PVN increase blood pressure and drinking in Sprague-Dawley rats?
Population
Sprague-Dawley rats, anesthetized and awake
Comparison
Microinfusion of ANG II vs ANG III into PVN, with or without ANG receptor antagonist sarthran pretreatment
Design
Preclinical experimental study with dose-dependent microinfusions
Authors
Loading...
Supports PVN angiotensin signaling in rat BP and thirst control; leaves open human translational relevance.
Does microinfusion of ANG II and III into the PVN increase blood pressure and drinking in Sprague-Dawley rats?
The paraventricular nucleus plays a critical role in mediating central angiotensin effects on body water homeostasis and blood pressure regulation in rats.
Jensen et al. (1992) studied this question. Angiotensin II and III microinfusion into the paraventricular nucleus vs. Sarthran pretreatment was evaluated on Blood pressure, heart rate, and drinking. Microinfusion of angiotensin II and III into the paraventricular nucleus produced dose-dependent elevations in systemic blood pressure, heart rate, and drinking in rats, which were blocked by sarthran.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: