Why the study?
Does pretreatment with angiotensin receptor antagonists in the PVN alter the physiological responses induced by angiotensin II in the MSA in rats?
Population
Male Holtzman rats weighing 250-300 g
Comparison
Injection of losartan, PD 123319, or [Sar1… vs Vehicle-treated rats and rats receiving…
Design
Preclinical
Follow-up
120 min
Authors
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Extends rodent mapping of AT1/AT2 modulation in PVN-MSA pathways; leaves open translation to human fluid balance or hypertension.
Does pretreatment with angiotensin receptor antagonists in the PVN alter the physiological responses induced by angiotensin II in the MSA in rats?
The study demonstrates that the angiotensinergic effect of the medial septal area on water and sodium homeostasis and blood pressure is modulated by AT1 and AT2 receptors in the paraventricular nucleus.
Camargo et al. (2002) studied this question.
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