Key result
Microinjection of the receptor Mas antagonist A-779 into the paraventricular hypothalamic nucleus of anesthetized rats significantly decreased renal sympathetic nerve activity (-26% vs -2% for vehicle).
Why the study?
Does microinjection of A-779 into the PVN reduce renal sympathetic nerve activity in anesthetized rats?
Population
Rats anesthetized with urethane (1.2 to 1.4 g/kg IP)
Comparison
Bilateral microinjections of A-779, a receptor… vs Vehicle (saline 0.9%)
Design
Preclinical
Authors
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Suggests endogenous Ang-(1-7) maintains basal sympathetic tone via PVN Mas receptors; leaves open relevance to hypertension or conscious models.
Does microinjection of A-779 into the PVN reduce renal sympathetic nerve activity in anesthetized rats?
Absolute Event Rate: -26% vs -2%
Blockade of endogenous Ang-(1-7) Mas receptors in the PVN reduces renal sympathetic nerve activity in anesthetized rats, suggesting a role in maintaining sympathetic tone.
Silva et al. (2005) studied this question. A-779 (receptor Mas antagonist) vs. Vehicle (saline 0.9%) was evaluated on Renal sympathetic nerve activity (RSNA). Microinjection of the receptor Mas antagonist A-779 into the paraventricular hypothalamic nucleus of anesthetized rats significantly decreased renal sympathetic nerve activity (-26% vs -2% for vehicle).
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