Key result
TNF1/2 genotype linked to higher predialysis TNF-alpha and IL-1beta in hemodialysis patients versus TNF1/1.
Why the study?
The effects of ACE and TNF-alpha-308 G > A genotypes on inflammatory cytokine production in hemodialysis patients were unclear.
Do ACE and TNF-alpha genotypes affect inflammatory cytokine levels in hemodialysis patients?
Observational (n=22)
Do ACE and TNF-alpha genotypes affect inflammatory cytokine levels in hemodialysis patients?
ACE and TNF-alpha-308 G > A gene polymorphisms may modulate proinflammatory cytokine production and chronic inflammation in hemodialysis patients.
TNF1/2 genotype associated with higher cytokines in hemodialysis; hypothesis-generating for genotype-inflammation links pending prospective trials.
BACKGROUND: Renin-angiotensin system (RAS) was suggested to modulate inflammatory cytokine production. Angiotensin II was consistently shown to increase production of tumor necrosis factor alpha (TNF-alpha). However, inflammatory cytokines and RAS were modulated by genetic polymorphisms such as TNF-alpha-308 G > A and angiotensin-converting enzyme (ACE) I/D gene polymorphisms. The aim of this study was to investigate the effects of ACE and TNF-alpha genotypes on inflammatory cytokines in hemodialysis (HD) patients. METHODS: ACE I/D and TNF-alpha-308 G > A genotypes, pre- and postdialysis plasma renin activity (PRA), serum ACE, interleukin-1 beta (IL-1beta), and TNF-alpha levels were determined in 22 HD patients. RESULTS: Predialysis serum ACE activity is correlated with TNF-alpha (r = 0.63; P = 0.01), and PRA was correlated with IL-1beta levels (r = 0.49; P = 0.02). Pre/postdialysis IL-1beta and TNF-alpha were similar in DD and II/ID ACE genotypes. Predialysis TNF-alpha and IL-1beta (32.4 +/- 5; 35.1 +/- 4.2 vs. 28.1 +/- 3.7; 26.5 +/- 6.2 pg/mL; P < 0.05) and postdialysis TNF-alpha levels (30.4 +/- 1.4 vs. 28.4 +/- 0.82 pg/mL; P < 0.05) were significantly higher in TNF1/2 than TNF1/1 patients. CONCLUSION: ACE and TNF-alpha-308 G > A (1/2) gene polymorphisms may contribute to modulation of proinflammatory cytokine production and hence chronic inflammation in HD patients.
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Gençtoy et al. (2005) conducted an observational in Hemodialysis (n=22). TNF-alpha-308 G > A and ACE I/D gene polymorphisms vs. Different genotypes (e.g., TNF1/1 vs TNF1/2) was evaluated on Inflammatory cytokine levels (TNF-alpha and IL-1beta) (p=<0.05). In hemodialysis patients, predialysis TNF-alpha and IL-1beta levels were significantly higher in those with the TNF1/2 genotype compared to the TNF1/1 genotype (P<0.05).
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