Induction of Voriconazole Metabolism by Rifampin in a Patient with Acute Myeloid Leukemia: Importance of Interdisciplinary Communication To Prevent Treatment Errors with Complex Medications

Voriconazole is metabolized by the CYP450 isoenzymes 2C19 and 3A4 and, to a lesser extent, by CYP2C9 ([3][1]). Several drug-drug interactions with voriconazole can be expected because many other drugs are also transformed by these enzymes, leading to a contraindication for coadministration of