December 17, 2004Arteriosclerosis Thrombosis and Vascular Biology
Associations of the UCP2 Gene Locus With Asymptomatic Carotid Atherosclerosis in Middle-Aged Women
Key result
UCP2 promoter polymorphisms are modestly linked to asymptomatic carotid atherosclerosis in high-risk middle-aged women.
- n=1,334
Why the study?
Reactive oxygen species contribute to atherogenesis, and the role of UCP2 gene polymorphisms in asymptomatic carotid atherosclerosis in humans was unclear.
Are UCP2 gene locus polymorphisms associated with asymptomatic carotid atherosclerosis in high-risk subjects?
Population
1334 participants of the Salzburg Atherosclerosis Prevention Program in Subjects at High Individual Risk (SAPHIR)
Comparison
-866G/A and 45nt-del/ins UCP2 gene polymorphisms vs alternative genotypes
Design
Observational genetic association study with functional cellular assays
Authors
Discussion
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Member takes
Implication
Association in middle-aged women is hypothesis-generating; larger studies needed to confirm UCP2 role in carotid atherosclerosis.
Study Design
Type
Observational (n=1,334)
Structured PICO
Are UCP2 gene locus polymorphisms associated with asymptomatic carotid atherosclerosis in high-risk subjects?
P
Population
1,334 middle-aged participants at high individual risk evaluated for the association between UCP2 gene polymorphisms and asymptomatic carotid atherosclerosis.
E
Exposure
UCP2 gene locus polymorphisms (-866G/A and 45nt-del/ins)
C
Comparator
Alternative genotypes/alleles
O
Outcome
Asymptomatic carotid atherosclerosissurrogate
The UCP2 gene locus polymorphisms are modestly associated with asymptomatic carotid atherosclerosis in women, supporting a role for UCP2 in atherogenesis.
Cite This Study
Oberkofler et al. (2004) conducted an observational in Asymptomatic carotid atherosclerosis (n=1,334). UCP2 gene -866G/A and 45nt-del/ins polymorphisms vs. Alternative genotypes was evaluated on Asymptomatic carotid atherosclerosis. In a study of 1,334 high-risk participants, the UCP2 -866G/A promoter polymorphism and 2-loci haplotypes were modestly associated with asymptomatic carotid atherosclerosis in middle-aged women.