Synthesis, neurotropic activity and SAR of new S-alkyl derivatives of 8- pyrazol-1-yl pyrano[3,4-c]pyridines

8-Hydrazino-3,3-dimethyl-6-thioxo-3,4,6,7-tetrahydro-1H-pyrano[3,4-c]pyridine was synthesized by a newly developed method.Pyrazolo substituted 6-thioxo-and S-alkyl-derivatives of the pyrano[3,4-c]pyridines have also been synthesized.In this work, 8-(3,5-dimethyl-1H-pyrazol-1-yl)-3,3-dimethyl-6-oxo-3,4,6,7-tetrahydro-1Hpyrano[3,4-c]pyridine-5-carbonitrile was also synthesized via an intramolecular nucleophilic substitution (Smiles rearrangement).The study of the neurotropic activity of the synthesized compounds was carried out using convulsive models (pentylenetetrazole and maximal electroshock) and the rotating rod model was used to study central myorelaxation.Compounds were found to antagonize corazole, but did not exhibit muscle relaxation at the studied doses, while simultaneously, they showed anxiolytic and antidepressant psychotropic activity.