Key result
Worsening renal function in HF is linked to imminent hospitalization and ~92% higher mortality.
Why the study?
The natural course of worsening renal function and its influence on heart failure prognosis in the community setting was unknown.
Does worsening renal function or severe chronic kidney disease increase the risk of hospitalisation and death in community-dwelling heart failure patients?
Case-Control (n=50,114)
Yes
Does worsening renal function or severe chronic kidney disease increase the risk of hospitalisation and death in community-dwelling heart failure patients?
Odds Ratio: 1.92 (95% CI 1.79–2.06)
In community-dwelling heart failure patients, severe chronic kidney disease and worsening renal function, but not moderate chronic kidney disease, are strongly associated with imminent hospitalisation and death.
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May warrant closer renal monitoring in community HF; leaves open whether interventions alter outcomes.
Testani et al. (2018) conducted a case-control in Heart failure (n=50,114). Worsening renal function (WRF) vs. No worsening renal function was evaluated on Mortality (OR 1.92, 95% CI 1.79-2.06). Worsening renal function in community heart failure patients is significantly associated with imminent hospitalization (OR 1.50; 95% CI 1.37-1.64) and mortality (OR 1.92; 95% CI 1.79-2.06).
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