Key result
Bipolar disorder linked to ~41% higher cardiovascular risk and greater vascular age versus healthy controls.
Why the study?
Bipolar disorder is associated with considerable morbidity and premature mortality mainly due to somatic causes, but detailed cardiovascular risk profiles in adults with BD are not well characterized.
Do adults with bipolar disorder have increased cardiovascular risk and worse physical, biochemical, and physiological profiles compared to healthy controls?
Observational (n=94)
Do adults with bipolar disorder have increased cardiovascular risk and worse physical, biochemical, and physiological profiles compared to healthy controls?
Absolute Event Rate: 3.1% vs 2.2%
p-value: p=≤0.05
Adults with bipolar disorder exhibit significantly higher estimated cardiovascular risk, vascular age, and atherogenic/inflammatory markers compared to healthy controls, highlighting the need for targeted cardiovascular screening and lifestyle interventions in this population.
Supports CV risk evaluation in bipolar disorder; hypothesis-generating for causality and interventions.
INTRODUCTION: Bipolar disorder (BD) is associated with considerable morbidity and premature mortality, mainly due to somatic causes. This study aims to determine some physical, exercise capacity-related physiological variables and biochemical markers of health status in adults (45.4 ± 13.1 years) with BD (n = 65) compared to a healthy control (HC) population (n = 29) sample and to estimate cardiovascular risk (CVR) through different methods in the BD group. METHODS: Multiple assessments included body composition, cardiorespiratory fitness (CRF), and biochemical parameters. CVR was calculated using the Framingham Heart Study, SCORE2, and relative risk methods. RESULTS: ; and cardiorespiratory optimal point, 27.9 ± 4.2 vs. 23.6 ± 4.2 ventilation/oxygen uptake ratio, p ≤ 0.05), biochemical concentrations of atherogenic indexes (total cholesterol/high-density lipoprotein cholesterol ratio, 4.1 ± 1.5 vs. 3.3 ± 1.0; and triglycerides/high-density lipoprotein cholesterol ratio, 2.8 ± 2.3 vs. 1.5 ± 1.0, p ≤ 0.05), and inflammatory C-reactive protein (3.8 ± 10.2 vs. 0.9 ± 1.05 mg/dL, p ≤ 0.05). Consequently, CVR showed higher values (p ≤ 0.05) in BD (high risk, 3.1%) compared to HC (low-to-moderate risk, 2.2%) participants, according to SCORE2, higher (p ≤ 0.05) vascular age (49.8 years) than chronological age (45.8 years), with a significant difference (p = 0.005) compared to HC. CONCLUSIONS: This study highlights the importance of specific physical, biochemical, and physiological screening and CVR and vascular age assessment for people with BD. The practical application of these findings would prevent cardiovascular disease in BD and promote a healthier lifestyle as an adjuvant strategy to pharmacological intervention.
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Etxaniz‐Oses et al. (2025) conducted an observational in Bipolar disorder (n=94). Bipolar disorder vs. Healthy controls was evaluated on Cardiovascular risk according to SCORE2 (p=≤0.05). Bipolar disorder was associated with higher cardiovascular risk compared to healthy controls (3.1% vs 2.2%, p≤0.05) and significantly higher vascular age.
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