Key result
Adolescent bipolar disorder is linked to lower cardiorespiratory fitness and altered regional brain structure.
Why the study?
Cardiovascular disease is prevalent and premature in bipolar disorder, but there is a gap in knowledge regarding cardiorespiratory fitness in bipolar disorder, especially its relationship with brain structure.
Is cardiorespiratory fitness reduced in adolescents with bipolar disorder compared to healthy controls, and does it correlate with brain structure?
Cross-Sectional (n=107)
No
Is cardiorespiratory fitness reduced in adolescents with bipolar disorder compared to healthy controls, and does it correlate with brain structure?
Adolescents with bipolar disorder exhibit reduced cardiorespiratory fitness compared to healthy controls, which correlates with structural brain differences and depression symptoms.
Supports fitness assessment in adolescent bipolar disorder; leaves open whether exercise modifies brain structure or symptoms.
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Popel et al. (2020) conducted a cross-sectional in Bipolar Disorder (n=107). Bipolar disorder vs. Healthy controls was evaluated on Cardiorespiratory fitness (power/weight in watts/kilogram). Cardiorespiratory fitness was reduced among adolescents with bipolar disorder compared to healthy controls, and was differentially associated with brain structure in frontal, parietal, and occipital regions.
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