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Chronic kidney disease remains a major public health burden worldwide with no ideal treatment besides dialysis or kidney transplantation.1,2 Promoting kidney regeneration is a promising strategy to treat patients with end-stage renal disease. Mammalian kidney can partially repair damaged nephrons in the condition of minor injury and progress to irreversible renal fibrosis with severe injury.3,4 By contrast, axolotl (Ambystoma mexicanum) exhibits a remarkable ability to regrow multiple body parts, including its entire limbs, the tail, ocular tissues, liver, heart, and even brain.
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Chen et al. (2023) studied this question.
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