Key result
Seven commercial infectious bursal disease vaccines show highly variable virulence and immunosuppressive properties.
Why the study?
The pathogenicity and immunosuppressive effects of commercially available intermediate infectious bursal disease vaccine strains in SPF chickens were not well characterized.
Do different commercially available intermediate IBD vaccines vary in their pathogenicity and immunosuppressive effects in SPF chickens?
Do different commercially available intermediate IBD vaccines vary in their pathogenicity and immunosuppressive effects in SPF chickens?
Commercially available 'intermediate' IBD vaccines exhibit significant variability in pathogenicity and immunosuppression in chickens, ranging from mild to highly virulent.
Variable virulence among commercial IBD vaccines may affect flock protection; leaves open optimal selection pending field validation.
This study was conducted to test the pathogenicity and immunosuppressive effects of seven commercially available infectious bursal disease (IBD) vaccines. These vaccine strains are intermediate in their pathogenicity in susceptible specific-pathogen-free (SPF) chickens. One-day-old and 3-week-old SPF chickens were vaccinated with these vaccines. Two weeks after IBD vaccination, they were vaccinated with Newcastle disease virus (NDV). The pathogenic and immunosuppressive effects of the IBD vaccines were evaluated by the antibody response to NDV vaccination, the bursa: body weight index, and histopathological lesions of the bursa. It was found that these strains were highly variable in their virulence and immunosuppressive properties. Three of the strains tested were found to be highly virulent and immunosuppressive; two others were moderate; and two could be classified as mild.
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Mazariegos et al. (1990) studied Infectious bursal disease. Seven commercially available infectious bursal disease (IBD) vaccines was evaluated on Antibody response to NDV vaccination, bursa:body weight index, and histopathological lesions of the bursa. Seven commercially available infectious bursal disease vaccines showed highly variable virulence and immunosuppressive properties, with 3 being highly virulent, 2 moderate, and 2 mild.
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