Key result
Kimura's disease presents with painless masses in 100% of cases alongside elevated eosinophils and IgE.
Why the study?
Kimura disease is an eosinophilic proliferative lymphoid disease with a rare incidence rate and nonspecific clinical symptoms, warranting investigation into its clinical characteristics, diagnosis, treatment, and prognosis.
What are the clinical characteristics, diagnosis, treatment, and prognosis of Kimura's disease?
Observational (n=20)
No
What are the clinical characteristics, diagnosis, treatment, and prognosis of Kimura's disease?
Kimura's disease typically presents with painless masses, elevated eosinophils, and high IgE, and can be diagnosed via pathology and treated with surgery, medical therapy, or radiotherapy.
May aid suspicion of Kimura's disease via classic triad; leaves open optimal management pending larger studies.
BACKGROUND: Kimura's disease (KD) is an eosinophilic proliferative lymphoid disease with rare incidence rate and nonspecific clinical symptoms. OBJECTIVES: To investigate the clinical characteristics, diagnosis, treatment, and prognosis of KD. MATERIALS AND METHODS: The clinical manifestations, laboratory examination, imaging examination, proposed treatment, and prognosis of 20 patients with KD treated in our hospital were retrospectively analyzed. RESULTS: All cases showed painless masses. The proportion of peripheral blood eosinophils rose in 18 cases (90%), the eosinophil count increased in 14 cases (70%) and the serum immunoglobulin E (IgE) levels were significantly increased in 5 patients (100%). Pathological examination revealed follicular hyperplasia, eosinophils infiltration, and tiny vessels proliferation in KD samples. CONCLUSIONS: KD should be considered when the patients suffered head and neck subcutaneous painless mass, increased peripheral blood eosinophils and raised serum IgE level. Pathological examination is the golden standard for diagnosing KD. Surgical intervention, medical treatments, and radiotherapy may be effective for KD treatment. SIGNIFICANCE: This study might shed a light on improving the diagnosis and treatment for KD.
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Zhuang et al. (2022) conducted an observational in Kimura's disease (n=20). Kimura's disease was evaluated on Clinical manifestations and laboratory findings. Kimura's disease presented with painless masses in 100% of cases, elevated peripheral blood eosinophils in 90%, and significantly increased serum IgE levels in 100% of tested patients.
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