Disease characteristics of 70 patients with Kimura disease

Objective To analyze the disease characteristics of patients with Kimura disease (KD) and provide reference for clinical practice. Methods Laboratory data of 70 patients with KD diagnosed based on pathology at the First Affiliated Hospital of Zhengzhou University from August 2012 to December 2021 were collected. Clinical manifestations, renal involvement, treatments, and risk factors for recurrence were analyzed. Results Among the 70 patients, 61 were male and 9 were female; 61.4% of patients (43/70) had focal masses only in the head and neck region and 30.0% (21/70) had masses not restricted to the head and neck; 52.9% (37/70) had pruritus. The proportion of eosinophils in peripheral blood was elevated in 80.0% of patients (56/70), and the level of serum immunoglobulin (Ig)E was increased in 96% (24/25). Renal damage was a complication in 21.8% of patients (12/55). Serum albumin and total protein levels were significantly lower in patients with as compared to those without renal impairment. Of the 70 patients, 37 had disease recurrence following treatment (surgical resection, oral corticosteroids, immunosuppressants, radiotherapy, or combinations thereof). Risk factors for KD recurrence were percentage of eosinophils in peripheral blood ≥ 20%, maximum diameter of masses ≥ 3 cm, and masses at multiple sites ( p < 0.05). Conclusion KD is a systemic disease involving multiple organs, especially the kidney. A better understanding of disease pathogenesis can lead to the development of effective treatments that improve the prognosis of patients.