Key result
Remission of membranous nephropathy in a 12-year-old boy with Kimura's disease was achieved using oral prednisolone and tacrolimus therapy.
Why the study?
Renal involvement in Kimura's disease is rare, especially in children.
Case Report (n=1)
Highlights the need to regularly monitor patients with Kimura's disease for the evolution of renal diseases, even if lymphadenopathy regresses.
Answers are grounded in this paper and cite their sources.
Membranous nephropathy may occur years after pediatric KD without lymphadenopathy; extends the renal phenotype but remains hypothesis-generating.
Kimura's disease (KD) is a chronic inflammatory disorder characterized by nontender lymphadenopathy involving the head and neck region. Renal involvement in KD is rare, especially in children. We report a 12-year-old boy who had been previously treated for classical KD and had presented with anasarca and oliguria after 4 years. There were no swellings or lymphadenopathy. The kidney biopsy revealed membranous nephropathy. Remission was achieved with oral prednisolone and tacrolimus therapy. This patient highlights the need to regularly monitor patients with KD for the evolution of renal diseases, even if lymphadenopathy regresses. Serial monitoring for eosinophilia, inflammatory markers, and urine examination is needed to help identify subclinical disease early and prompt initiation of specific therapy.
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Loganathan et al. (2024) conducted a case report in Kimura's disease and membranous nephropathy (n=1). Oral prednisolone and tacrolimus therapy was evaluated on Remission. Remission of membranous nephropathy in a 12-year-old boy with Kimura's disease was achieved using oral prednisolone and tacrolimus therapy.
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