Key result
Two cases of Kimura's disease highlight variable presentation and frequent recurrences tied to therapy pitfalls.
Why the study?
Kimura's disease presents variably with frequent recurrences and lacks a standardized treatment protocol.
Case Report (n=2)
Kimura's disease presents with variable symptoms and frequent recurrences despite various treatment options.
Narrative review of Kimura's disease reinforces classic features; leaves open standardized management for renal involvement.
Kimura's disease (KD) is an allergic, inflammatory disorder of unknown cause. The typical presentation is in a young Oriental male with nontender subcutaneous swellings in the head and neck region, lymphadenopathy, peripheral eosinophilia, and elevated serum IgE. Many patients with KD also develop renal involvement. Treatment options range from conservative observation for asymptomatic patients to surgical excision, steroid therapy, and radiotherapy for symptomatic patients. Two cases of KD are presented. These emphasize not only the variability of disease presentation, but also the pitfalls of therapy leading to frequent recurrences. The literature is reviewed, summarizing patient presentation, differential diagnosis, current theories on causation, and therapy. A treatment protocol is also proposed.
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Messina-Doucet et al. (1998) conducted a case report in Kimura's disease (n=2). Two cases of Kimura's disease highlight the variability of disease presentation and the pitfalls of therapy leading to frequent recurrences.
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