Key result
Wing-weighting induces muscle hypertrophy and V-EMB myosin expression partially linked to satellite cell accumulation.
Why the study?
The role of satellite cells in expressing embryonic myosin isoforms during skeletal muscle hypertrophy and their contribution to myosin expression changes is unclear.
Population
Adult chickens with anterior latissimus dorsi muscle
Comparison
Wing-weighting for 1 and 7 days vs contralateral control
Design
Preclinical experimental study
Follow-up
1 and 7 days
Authors
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Avian model data warrant no change in clinical practice; leaves open non-satellite cell sources of myosin expression in hypertrophy.
In an avian model of skeletal muscle hypertrophy, recently incorporated nuclei from satellite cell division are one, but not the sole, source of embryonic myosin expression.
McCormick et al. (1994) studied Skeletal muscle hypertrophy. Wing-weighting vs. Contralateral control was evaluated on Ventricular-like embryonic (V-EMB) myosin expression and satellite cell progeny accumulation. Wing-weighting induced muscle hypertrophy and V-EMB myosin expression in mature fibers, which was partially associated with satellite cell progeny accumulation but not solely dependent on it.
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