Key result
Laparoscopic sleeve gastrectomy reduces Framingham risk scores in morbidly obese patients at 12 months.
Why the study?
The impact of laparoscopic sleeve gastrectomy on coronary heart disease risk reduction in morbidly obese patients was assessed.
Does laparoscopic sleeve gastrectomy reduce predicted coronary heart disease risk in morbidly obese patients?
Cohort (n=870)
No
Does laparoscopic sleeve gastrectomy reduce predicted coronary heart disease risk in morbidly obese patients?
p-value: p=<0.0001
Laparoscopic sleeve gastrectomy significantly reduces the predicted 10-year coronary heart disease risk (Framingham risk score) and improves cardiovascular risk factors in morbidly obese patients at 6 and 12 months postoperatively.
May lower predicted CHD risk after sleeve gastrectomy; hypothesis-generating and should not yet change practice.
PURPOSE: To assess the reduction of 6 and 12 months postoperatively of Framingham risk score in morbidly obese patients with laparoscopic sleeve gastrectomy (LSG). MATERIAL AND METHODS: In total, 870 morbid obesity patients received LSG in Taipei Medical University Hospital from June 2007 to June 2014 were retrospectively studied preoperatively, 6 and 12 months after surgery. The coronary heart disease risk was calculated using Framingham risk score. RESULTS: , respectively, at 6 and 12 months after surgery (P < 0.0001). At 6 and 12 months after LSG, there was a marked improvement on lipid profile as well as a significant decline in the prevalence of diabetes mellitus, systemic hypertension, and smoking. The Framingham risk score in men and women reduced from 3.2 ± 5.7, 6.1 ± 5.7 preoperatively to 1.4 ± 5.9, 3.3 ± 5.9 and 0.1 ± 6.2, 2.8 ± 6.1, respectively, at 6 and 12 months after surgery (P < 0.0001). CONCLUSIONS: Laparoscopic sleeve gastrectomy is efficient not only in the reduction of obesity and its related comorbidities but also in decreasing the long-term coronary event risk. Early intervention for the high-risk group is strongly recommended.
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Huang et al. (2017) conducted a cohort in Morbid obesity (n=870). Laparoscopic sleeve gastrectomy vs. Preoperative baseline was evaluated on Framingham risk score at 6 and 12 months (p=<0.0001). Laparoscopic sleeve gastrectomy significantly reduced the Framingham risk score in morbidly obese men and women at 6 and 12 months postoperatively (P<0.0001).
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