Key result
Calcium and thrombomodulin inhibit thrombin-mediated protein S cleavage, making it an unlikely physiological control mechanism.
Why the study?
The control mechanisms for thrombin cleavage of protein S and its impact on protein S cofactor activity were not fully understood.
Physiological concentrations of calcium and thrombomodulin inhibit thrombin-mediated cleavage of protein S, indicating this cleavage is not a physiological regulatory mechanism.
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Questions physiological relevance of thrombin-mediated protein S cleavage; leaves open its role in human coagulation.
Mitchell et al. (1986) studied this question. Thrombin was evaluated on Cleavage of protein S and loss of cofactor activity. Inhibitory effects of calcium and thrombomodulin on thrombin-mediated cleavage of protein S suggest this event is unlikely to represent a physiological control of protein S activity.
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