Key result
Forced circadian misalignment from nightshift work independently increases cardiometabolic risk and predisposes to CVD.
Why the study?
Forced misalignment of circadian cycles is an independent cardiometabolic risk factor that may predispose certain groups to cardiovascular disease.
Circadian clock dysfunction, often caused by lifestyle factors, is emerging as an independent risk factor for cardiometabolic and cardiovascular diseases.
Governing a large amount of cellular processes in mammalian cells is a 24-h regulatory mechanism known as the circadian clock. Through the release of neurohormonal factors, the master central clock is able to regulate the otherwise independent peripheral clocks situated in all vital organs. It has recently been shown that forced misalignment of the circadian cycles, often as a consequence of lifestyle factors, is an independent cardiometabolic risk factor and may thus potentially predispose certain groups, such as nightshift workers, to cardiovascular disease. In this review, we will analyse some of the recent advances regarding circadian clock dysfunction and the development of cardiovascular diseases. Finally, we will touch on the developing link between circadian dysfunction and myocardial infarctions.
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Stöhr et al. (2014) conducted a review in Cardiovascular disease and cardiometabolic risk. Circadian clock dysfunction / forced misalignment of circadian cycles was evaluated. Forced misalignment of circadian cycles, often due to lifestyle factors like nightshift work, is an independent cardiometabolic risk factor that may predispose individuals to cardiovascular disease.
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