Key result
miR-205 overexpression alleviates lipid accumulation in NAFLD models by inhibiting NEU1.
Why the study?
The study was conducted to explore the role of miR-205 in non-alcoholic fatty liver disease (NAFLD) and its underlying mechanism.
Does miR-205 overexpression ameliorate lipid accumulation in models of non-alcoholic fatty liver disease?
Does miR-205 overexpression ameliorate lipid accumulation in models of non-alcoholic fatty liver disease?
Overexpression of miR-205 ameliorates lipid accumulation in NAFLD models by targeting NEU1, suggesting a potential therapeutic target.
Preclinical support for miR-205/NEU1 axis in NAFLD models; leaves open translation to human therapy.
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Hu et al. (2019) studied Non-alcoholic fatty liver disease (NAFLD). miR-205 overexpression vs. Control was evaluated on Lipid accumulation. Overexpression of miR-205 alleviated lipid accumulation in in vitro and in vivo models of NAFLD by targeting and inhibiting NEU1.
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