Key result
Cap-independent translational enhancers emerge as a proposed alternative to cellular IRESs for translation initiation.
Why the study?
The concept of cellular IRES-elements as a mechanism for translation initiation under cap-dependent inhibition has been challenged by recent studies revealing artifacts and confusion with cap-independent mechanisms.
Comparison
Cap- and IRES-independent scanning mechanism vs cellular IRES-directed translation initiation
Design
Review analyzing sources of artifacts and control experiments for IRES identification
Authors
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Challenges cellular IRES paradigm for cap-independent translation; leaves open experimental validation of CITE scanning.
Proposes a cap- and IRES-independent scanning mechanism utilizing CITE as an alternative to the cellular IRES concept for translation initiation.
Shatsky et al. (2010) reported a review. Cap- and IRES-independent scanning mechanism vs. Cellular IRESs was evaluated. A cap- and IRES-independent scanning mechanism utilizing cap-independent translational enhancers (CITE) is proposed as an alternative to the concept of cellular IRESs for translation initiation.
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