Key result
Preoperative symptomatic HF linked to ~140% higher perioperative mortality in CABG patients with ventricular dysfunction.
Why the study?
Does the presence of symptomatic heart failure or reoperation predict increased perioperative mortality in patients with left ventricular dysfunction undergoing CABG?
Cohort (n=900)
Does the presence of symptomatic heart failure or reoperation predict increased perioperative mortality in patients with left ventricular dysfunction undergoing CABG?
Odds Ratio: 2.4
Absolute Event Rate: 7.7% vs 3.5%
p-value: p=0.01
Symptomatic heart failure and reoperation are significant predictors of increased perioperative mortality in patients with severe left ventricular dysfunction undergoing CABG.
Flags higher perioperative mortality risk in LV-dysfunction CABG; leaves open whether preoperative optimization improves outcomes.
BACKGROUND: Preoperative characteristics may influence morbidity and mortality in patients undergoing coronary artery bypass grafting (CABG). The CABG Patch Trial was designed to assess the impact of prophylactic insertion of an implantable cardioverter-defibrillator in patients undergoing high-risk CABG. This database was used to investigate the influence of symptomatic congestive heart failure (CHF) and angina on morbidity and mortality in CABG patients with ventricular dysfunction. METHODS AND RESULTS: Data were analyzed for 900 randomized patients with an ejection fraction </=35% and an abnormal signal-averaged ECG. Single-variable and stepwise multiple logistic regression analyses were used for mortality and length-of-stay (LOS) data. Severity of CHF and angina was graded by the New York Heart Association (NYHA) and Canadian Cardiovascular Society (CCS) classifications, respectively. Perioperative mortality was 3.5% in 454 patients without clinical signs of heart failure versus 7.7% in 443 patients with NYHA class I to IV heart failure (P=0.018). By multiple logistic regression analysis, mortality was significantly higher in patients with preoperative symptomatic (NYHA class I to IV) heart failure (odds ratio, 2.4; P=0.01) or reoperation (odds ratio, 3.8; P<0.0001). Mortality was not significantly influenced by age, sex, the presence or severity of angina, hypertension, left main coronary artery disease, pulmonary disease, or severity of CHF (although LOS was increased 0.7 days per NYHA class). Patients with a history of stroke had a higher rate of perioperative stroke (16.4% versus 3.6%, P=0.001) and an increased LOS (by 3.5 days). CONCLUSIONS: Symptomatic heart failure and reoperation are predictors of increased operative mortality in patients with ventricular dysfunction and a positive signal-averaged ECG. Conversely, patients without heart failure symptoms may undergo CABG with relatively low mortality despite low ejection fraction. LOS is prolonged significantly by advanced age, history of stroke, and the presence and severity of heart failure.
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Argenziano et al. (1999) conducted a cohort in Left ventricular dysfunction in patients undergoing coronary artery bypass grafting (n=900). Preoperative symptomatic heart failure vs. No clinical signs of heart failure was evaluated on Perioperative mortality (OR 2.4, p=0.01). Preoperative symptomatic heart failure in patients undergoing CABG with ventricular dysfunction was associated with increased perioperative mortality (7.7% vs 3.5%; OR 2.4, P=0.01).
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