Key result
Rat retinas express AT1 mRNA in ~80% of samples unlike other ocular tissues.
Why the study?
The localization of angiotensin II type 1 receptor mRNA in several ocular tissues had not been fully elucidated.
Population
Wistar-Kyoto rats ocular tissues
Design
Reverse transcription polymerase chain reaction study
Authors
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Hypothesis-generating for retinal AT1 in rodent models; leaves open relevance to human ocular disease.
Absolute Event Rate: 80% vs 0%
p-value: p=0.0238
Murata et al. (2010) studied this question. Retinal tissue vs. Other ocular tissues (cornea, sclera, iris, ciliary body, and choroid) was evaluated on Expression of AT1 mRNA (p=0.0238). AT1 mRNA was significantly more expressed in the retina of Wistar-Kyoto rats (4 of 5 samples positive) compared to other ocular tissues (0 of 5 samples positive) (p=0.0238).
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