Key result
The novel Mas receptor was detected in rat eye tissue, and treatment with an ARB blocked a part of AT1 receptors but had no clear effect on AT2 receptors.
Population
Spontaneously hypertensive rats, double transgenic rats harbouring human renin and angiotensinogen genes…
Comparison
Oral pretreatment with an Angiotensin II type 1… vs No ARB pretreatment
Design
Preclinical
Authors
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Mas receptor detection in rat eyes is hypothesis-generating; leaves open any role in human ocular disease or ARB effects.
The novel Mas receptor is expressed in rat eye tissue, and ocular AT1 receptor density appears independent of systemic blood pressure levels.
Vaajanen et al. (2009) studied Arterial hypertension. Angiotensin II type 1 receptor blocker (ARB) vs. Untreated rats / normotensive controls was evaluated on mRNA expression of AT1a, AT2, and Mas receptors in eye tissues. The novel Mas receptor was detected in rat eye tissue, and treatment with an ARB blocked a part of AT1 receptors but had no clear effect on AT2 receptors.
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