Key result
Remitted MDD is linked to attenuated cognitive control network connectivity versus healthy controls.
Why the study?
No studies had evaluated whether impaired connectivity within the cognitive control network is present and temporally stable in individuals with remitted major depressive disorder.
Does resting-state functional connectivity within the cognitive control network differ between individuals with remitted depression and healthy controls?
Population
52 unmedicated young adults with remitted MDD and 47 matched healthy controls
Comparison
Individuals with remitted MDD vs healthy controls
Design
Observational resting-state functional connectivity MRI study
Authors
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Hypothesis-generating for trait biomarkers in remitted MDD; leaves open causality and precludes practice change without longitudinal data.
Observational (n=99)
Does resting-state functional connectivity within the cognitive control network differ between individuals with remitted depression and healthy controls?
Attenuated connectivity within the cognitive control network may represent a stable biomarker for trait phenotypes of depression risk in individuals with remitted major depressive disorder.
Stange et al. (2017) conducted an observational in remitted major depressive disorder (n=99). Remitted major depressive disorder vs. Healthy controls was evaluated on Resting-state functional connectivity within the cognitive control network. Remitted MDD was associated with attenuated intrinsic connectivity within the cognitive control network compared to healthy controls, mediating relationships with cognitive risk factors for depression.
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