Key result
AMI is linked to ~13-fold higher BNP, correlating with LV systolic dysfunction severity.
Why the study?
The study aimed to observe brain natriuretic peptide release in acute myocardial infarction and its relation to infarction extent and left ventricle systolic dysfunction.
Are BNP levels elevated in patients with acute myocardial infarction compared to controls, and do they correlate with systolic dysfunction and infarct extent?
Population
75 patients with acute myocardial infarction and 61 age- and gender-matched controls
Comparison
Acute myocardial infarction patients vs controls
Design
Case-control study
Authors
Loading...
May support BNP as a marker of LV dysfunction in acute MI; hypothesis-generating and should not yet change practice.
Case-Control (n=136)
No
Are BNP levels elevated in patients with acute myocardial infarction compared to controls, and do they correlate with systolic dysfunction and infarct extent?
Absolute Event Rate: 462.875% vs 35.356%
p-value: p=<0.001
BNP is significantly elevated in acute myocardial infarction and correlates with the extent of infarction and severity of left ventricular systolic dysfunction, suggesting its utility as a quick biochemical marker for these parameters.
Durak-Nalbantić et al. (2012) conducted a case-control in Acute myocardial infarction (n=136). Acute myocardial infarction vs. Healthy controls was evaluated on Plasma BNP level (pg/ml) (p=<0.001). Acute myocardial infarction was associated with significantly elevated plasma BNP levels compared to healthy controls (462.875 pg/ml vs 35.356 pg/ml, p<0.001), with levels correlating to the severity of left ventricular systolic dysfunction.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: