What question did this study set out to answer?

To evaluate the association between plasma B-type natriuretic peptide (BNP) concentration and myocardial infarct size in patients with acute myocardial infarction.

January 1, 2014Genetics and Molecular ResearchOpen Access

Association of plasma B-type natriuretic peptide concentration with myocardial infarct size in patients with acute myocardial infarction

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Why the study?

Is plasma BNP concentration associated with myocardial infarct size in patients with acute myocardial infarction?

Key Points

To evaluate the association between plasma B-type natriuretic peptide (BNP) concentration and myocardial infarct size in patients with acute myocardial infarction.
Enrolled 80 patients with acute myocardial infarction and 30 healthy volunteers as controls.
Assessed cardiac magnetic resonance imaging and measured plasma BNP concentrations to analyze the relationship between BNP levels, infarct size, and left ventricular ejection fraction.
Plasma BNP concentration positively correlated with myocardial infarct size (r = 0.645, P < 0.0005) and negatively correlated with left ventricular ejection fraction (r = 0.297, P = 0.047).
Multiple regression analysis showed myocardial infarct size was the only variable independently associated with BNP levels (r² = 0.32, F = 7.712, P = 0.007).
A plasma BNP cutoff of 150 pg/mL predicted myocardial infarct sizes exceeding 10% with 85.1% sensitivity and 70.4% specificity.

Structured PICO

Is plasma BNP concentration associated with myocardial infarct size in patients with acute myocardial infarction?

Population

110 participants, comprising 80 patients with acute myocardial infarction (AMI) and 30 healthy volunteers.

Intervention

Measurement of plasma B-type natriuretic peptide (BNP) concentration

Comparator

Healthy volunteers (n=30)

Outcome

Correlation between plasma BNP concentration and myocardial infarct (MI) size measured by magnetic resonance imagingsurrogate

Plasma BNP concentration correlates significantly with myocardial infarct size in AMI patients and may serve as a useful clinical biomarker to estimate infarct size.

Discussion

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Implication

BNP may aid noninvasive MI size estimation in AMI; leaves open its incremental value for risk stratification or outcomes.

Cite This Study

Niu et al. (2014) studied this question.

synapsesocial.com/papers/6a87c241f762332bf8fe7a58 https://doi.org/10.4238/2014.february.21.6

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Association of plasma B-type natriuretic peptide concentration with myocardial infarct size in patients with acute myocardial infarction

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Association of plasma B-type natriuretic peptide concentration with myocardial infarct size in patients with acute myocardial infarction

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider