Key result
Dietary n-3 fatty acids reduce triglycerides across all lipoprotein fractions, unlike evening primrose oil.
Why the study?
The effects of dietary supplementation with n-6 and n-3 long-chain polyunsaturated fatty acids on serum lipoproteins and platelet function in hypertriglyceridaemic patients were not fully characterized.
Does dietary supplementation with n-6 or n-3 polyunsaturated fatty acids improve serum lipoproteins and platelet function in patients with hypertriglyceridaemia?
Comparison
Evening primrose oil rich in GLA vs marine oil concentrate containing n-3 fatty acids vs olive oil placebo
Design
Double-blind cross-over randomized controlled trial
Follow-up
8 + 8 weeks
Authors
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n-3 fatty acids lower triglycerides across fractions in hypertriglyceridaemia; confirms lack of GLA effect and supports targeted n-3 use.
RCT (n=27)
Double-blind
Cross-over
Does dietary supplementation with n-6 or n-3 polyunsaturated fatty acids improve serum lipoproteins and platelet function in patients with hypertriglyceridaemia?
n-3 fatty acids, but not n-6 fatty acids (GLA), effectively lower triglycerides in patients with hypertriglyceridaemia.
Boberg et al. (1986) conducted an RCT in Hypertriglyceridaemia (n=27). Evening primrose oil (GLA) or marine oil concentrate (n-3 fatty acids) vs. Olive oil (placebo) was evaluated on Serum lipoproteins and platelet function. Dietary supplementation with n-3 fatty acids significantly decreased triglycerides in all lipoprotein fractions, whereas evening primrose oil (GLA) had no such triglyceride-lowering effect.
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