Flavonoids through the eyes of a pharmacologist. Antioxidant and anti-inflammatory activities

Review discusses the mechanisms of antioxidant and anti-inflammatory actions of flavonoids. In discussing the antioxidant effect detail the mechanisms of scavenging of reactive oxygen species, the chelation of transition metals, the activation of antioxidant enzymes. In consideration of anti-inflammatory action emphasis on the effects of flavonoids on the activity of the transcription factors and pathways involved in the formation of the inflammatory response. (For citation: Zverev YaF. Flavonoids through the eyes of a pharmacologist. Antioxidant and anti-inflammatory activities. Reviews on Clinical Pharmacology and Drug Therapy. 2017;15(4):5-13. doi: 10.17816/RCF1545-13).