Key result
Recombinant prolactin sharply reduces urine output in vasopressin-deficient rats but causes mild diuresis with intact vasopressin.
Why the study?
The renal effects of prolactin remain controversial and require re-examination using recombinant prolactin in the presence and absence of circulating vasopressin.
Does recombinant mouse prolactin affect urine and sodium excretion in rats in the presence or absence of circulating vasopressin?
Population
Anaesthetized Brattleboro rats with hereditary hypothalamic diabetes insipidus, Long Evans rats, and fluid-loaded Sprague-Dawley rats
Comparison
Recombinant mouse prolactin infusion vs NaCl vehicle controls
Design
Preclinical experimental study in anaesthetized rats
Authors
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Prolactin may differentially modulate diuresis by vasopressin status in rats; leaves open any role in human water balance disorders.
Does recombinant mouse prolactin affect urine and sodium excretion in rats in the presence or absence of circulating vasopressin?
p-value: p=<0.005
Recombinant prolactin exerts a profound antidiuretic effect in the absence of circulating vasopressin, but a small diuretic effect when vasopressin is present.
Morrissey et al. (2001) studied Hereditary hypothalamic diabetes insipidus. Recombinant mouse prolactin (rmP) vs. 150 mmol/l NaCl vehicle was evaluated on Urine excretion (p=<0.005). Recombinant mouse prolactin induced a profound dose-dependent decrease in urine excretion in rats lacking vasopressin (P<0.005), but caused a small diuretic effect when vasopressin was present.
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