Key result
High LIPH expression linked to lower overall survival in breast cancer.
Why the study?
Although the importance of LIPH had been reported in several carcinomas, its expression pattern in breast cancer needed systematic assessment.
Does high LIPH expression predict worse overall survival in patients with breast cancer?
Observational (n=2,994)
Does high LIPH expression predict worse overall survival in patients with breast cancer?
p-value: p=0.0067 (TCGA) and <0.0001 (METABRIC)
High LIPH expression is an independent prognostic factor associated with worse overall survival in breast cancer patients.
High LIPH expression warrants no change in breast cancer management; leaves open its added prognostic value in prospective cohorts.
BACKGROUND: Lipase member H (LIPH), a novel member of the mammalian triglyceride lipase family, is localized on human chromosome 3q27-q28. Exploration of the importance of the new cancer-related gene LIPH in several carcinomas has been reported in previous studies. Our study aims to systematically assess the expression pattern of LIPH in breast cancer. METHODS: Our study explored 2994 breast cancer samples with transcriptome data from the Cancer Genome Atlas (TCGA) and the Molecular Taxonomy of Breast Cancer International Consortium (METABRIC) datasets. We systematically evaluated the mRNA expression of LIPH in breast cancer and the overall survival (OS) of patients. The protein expression of LIPH in breast cancer was evaluated with the Human Protein Atlas. We also explored the relationship between LIPH and the immune microenvironment in pan-cancer. RESULTS: Both mRNA and protein expression LIPH were found to be upregulated in breast cancer tumors. The overall survival rate of patients with high LIPH expression was lower than those of patients with low LIPH expression in both the TCGA dataset (p=0.0067) and METABRIC dataset (p<0.0001). Outcomes of the multivariate analysis found that the level of LIPH expression was an independent prognostic factor in both TCGA (p=0.001) and METABRIC (p=0.019) databases. The outcomes of the univariate analysis showed that LIPH was an important prognostic factor (p=0.01 in TCGA dataset, p=0.001 in METABRIC dataset). In the TCGA dataset, outcomes showed that LIPH expression was negatively correlated with the AJCC (American Joint Committee on Cancer) stage (p=2.3e-05) and triple-negative breast cancer (TNBC) tissues (p=3.1e-10). High LIPH expression showed lower OS in the TNBC subtype (P=0.011). CONCLUSION: Compared to normal tissues, the expression of LIPH was higher in breast cancer tissues in both mRNA and protein levels. This study showed that the high level of LIPH expression might be related to the worse prognosis of breast cancer.
No takes yet. Share an insight, caveat, or question.
Gao et al. (2021) conducted an observational in Breast cancer (n=2,994). High LIPH expression vs. Low LIPH expression was evaluated on Overall survival (p=0.0067 (TCGA) and <0.0001 (METABRIC)). High LIPH expression was associated with lower overall survival in breast cancer patients compared to low expression in both the TCGA (p=0.0067) and METABRIC (p<0.0001) datasets.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: