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July 28, 2026Frontiers in Sports and Active LivingOpen Access

Higher depressive symptoms linked to ~7% lower odds of low-to-moderate vigorous physical activity versus none.

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Why the study?

The proportion of vigorous physical activity within total physical activity and its associations with depressive symptoms and other factors among sufficiently active medical students remain underexplored.

Are depressive symptoms and sociodemographic factors associated with the proportion of vigorous physical activity among active medical students?

Population

656 sufficiently active fifth-year medical students from five universities in Serbia

Comparison

No VPA contribution vs low-to-moderate and higher VPA contribution within total PA

Design

Cross-sectional secondary analysis

Key result

Higher depressive symptom scores were associated with lower odds of having a low-to-moderate proportion of vigorous physical activity compared to no vigorous physical activity (OR 0.93).

Authors

KSKonstantinos StratakisJTJovana TodorovicMMMomcilo Mirkovic

Discussion

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Member takes

Overview

Depressive symptoms associated with lower vigorous activity proportion in active students; extends total-volume research but leaves open causality and clinical relevance.

Study Design

Type

Cross-Sectional (n=656)

Multicenter

Yes

Structured PICO

Are depressive symptoms and sociodemographic factors associated with the proportion of vigorous physical activity among active medical students?

P
Population
656 sufficiently active fifth-year medical students from five universities in Serbia, assessed for factors associated with the proportion of vigorous physical activity within total physical activity.
O
Outcome
Association between depressive symptoms (PHQ-9 scores) and proportion of vigorous physical activity within total physical activitypatient reported

Main Result

Odds Ratio: 0.93 (95% CI 0.86–0.99)

Among active medical students, depressive symptoms are associated with differences in the distribution of vigorous physical activity within total physical activity.

Limitations

  • Cross-sectional design precludes establishing causal relationships.
  • Self-reported data may introduce measurement error, particularly for physical activity recall and intensity misclassification.
  • Restricted to sufficiently active fifth-year medical students in Serbia, limiting generalizability to inactive students or other populations.
  • Lack of formal psychometric validation of the IPAQ-SF, PHQ-9, and other instruments specifically in Serbian medical students.
  • Potential residual confounding from unmeasured variables such as sleep quality, academic stress, and psychiatric history.
  • cross-sectional design
  • self-reported data

Cite This Study

Stratakis et al. (2026) conducted a cross-sectional in Sufficiently active medical students (n=656). Depressive symptoms (PHQ-9 score) vs. 0% vigorous physical activity (VPA) group was evaluated on Belonging to the 0.01%-30% VPA group compared to the 0% VPA group (OR 0.93, 95% CI 0.86-0.99). Higher depressive symptom scores were associated with lower odds of having a low-to-moderate proportion of vigorous physical activity compared to no vigorous physical activity (OR 0.93).

synapsesocial.com/papers/6aaa54d23581ab7f19083ec7https://doi.org/10.3389/fspor.2026.1870798
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