Key result
Angiotensin 1-7 requires neprilysin degradation into angiotensin 1-2 to enhance insulin secretion in mouse islets.
Why the study?
The role of neprilysin in mediating angiotensin-(1-7)-induced enhancement of glucose-stimulated insulin secretion and its proteolytic activity in islets was unclear.
Population
Neprilysin-deficient and wild-type mouse islets
Comparison
Angiotensin-(1-7) and neprilysin-derived peptides vs wild-type and neprilysin-deficient islets
Design
Preclinical study
Authors
Loading...
May warrant caution combining neprilysin inhibitors with angiotensin-(1-7) therapies; leaves open human translation.
The beneficial effects of angiotensin-(1-7) on insulin secretion require its degradation by neprilysin into angiotensin-(1-2), which signals via GPRC6A, suggesting caution when combining angiotensin-(1-7) therapies with neprilysin inhibitors.
Brar et al. (2017) studied Type 2 diabetes. Angiotensin-(1-7) was evaluated on Glucose-stimulated insulin secretion (GSIS). Angiotensin-(1-7) requires degradation by neprilysin into angiotensin-(1-2) to enhance glucose-stimulated insulin secretion via the GPRC6A receptor in mouse islets.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: