What question did this study set out to answer?

Investigate the subcellular localization of the voltage-gated potassium channel KV10.1 and determine its role in primary cilium disassembly and cell cycle-coupled tumor progression.

April 21, 2016EMBO ReportsOpen Access

Cyclic expression of the voltage‐gated potassium channel KV10.1 promotes disassembly of the primary cilium

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Authors

ASAraceli SánchezMax Planck Institute of Experimental Medicine DUDiana UrregoMax Planck Institute for Multidisciplinary Sciences LPLuis A. PardoElectrophysiology

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Implication

Experimental study reveals that potassium channel KV10.1 drives primary ciliary disassembly prior to mitosis, indicating a mechanistic link between ion channel activity and tumor proliferation.

Key Points

Investigate the subcellular localization of the voltage-gated potassium channel KV10.1 and determine its role in primary cilium disassembly and cell cycle-coupled tumor progression.
Conducted microscopic and biochemical assays to assess the localization of KV10.1 to the centrosome and primary cilium in healthy and proliferating cells.
Evaluated ciliary dynamics, cell cycle progression, and in vivo tumor formation following KV10.1 knockdown or targeted disruption of its ciliary localization.
KV10.1 concentrates at the centrosome and the primary cilium, where its cyclic expression triggers ciliary resorption immediately prior to mitosis.
Disrupting the ciliary localization of KV10.1 prevents primary cilium disassembly and abolishes KV10.1-driven tumor progression in vivo.
Knockdown of KV10.1 impairs ciliary disassembly, delays cell proliferation, and causes proliferating cells to retain prominent primary cilia.

Cite This Study

Sánchez et al. (2016) studied this question.

synapsesocial.com/papers/6aaa56dec14df864c354c27e https://doi.org/10.15252/embr.201541082

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Implication

Experimental study reveals that potassium channel KV10.1 drives primary ciliary disassembly prior to mitosis, indicating a mechanistic link between ion channel activity and tumor proliferation.

Cyclic expression of the voltage‐gated potassium channel KV10.1 promotes disassembly of the primary cilium

Discussion

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Implication

Key Points

Cite This Study

Cyclic expression of the voltage‐gated potassium channel KV10.1 promotes disassembly of the primary cilium

Discussion

Member takes

Implication

Key Points

Cite This Study

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