Key result
Among 15 pregnant women with Marfan syndrome, type-B aortic dissection occurred in 60% (3 of 5) of those with prior aortic root replacement compared to 10% (1 of 10) without prior replacement.
Why the study?
Does prior aortic root replacement affect the risk of type-B aortic dissection during pregnancy in women with Marfan syndrome?
Case Report (n=15)
Does prior aortic root replacement affect the risk of type-B aortic dissection during pregnancy in women with Marfan syndrome?
Answers are grounded in this paper and cite their sources.
Pregnant women with Marfan syndrome who have undergone prior aortic root replacement may be at a particularly high risk for type-B aortic dissection.
Sayama et al. describe the outcome of 17 pregnancies in 15 women with a clinical or genetic diagnosis of Marfan syndrome (MS), as per the revised Ghent criteria. Five women had undergone aortic root replacement prior to pregnancy, and ten women had not. A type-B aortic dissection AD(B) occurred in three of the five with prior aortic root replacement (ARR), and in one of the ten without ARR. This case series reminds us of critically important points in the management of pregnant women with MS who have undergone ARR.
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Johnson et al. (2017) conducted a case report in Marfan syndrome in pregnancy (n=15). Prior aortic root replacement vs. No prior aortic root replacement was evaluated on Type-B aortic dissection. Among 15 pregnant women with Marfan syndrome, type-B aortic dissection occurred in 60% (3 of 5) of those with prior aortic root replacement compared to 10% (1 of 10) without prior replacement.
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