Modified Mouse Model of Clostridioides difficile Infection as a Platform for Probiotic Efficacy Studies

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A modified mouse model of Clostridioides difficile infection serves as an effective platform for evaluating the efficacy of probiotic treatments. Novelty: ClaimNovelty.METHODOLOGICAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

Travis J. De Wolfe; Ashley Kates; Lauren Barko; Nasia Safdar

doi:10.1128/aac.00111-19

April 12, 2019Antimicrobial Agents and ChemotherapyOpen Access

Modified Mouse Model of Clostridioides difficile Infection as a Platform for Probiotic Efficacy Studies

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Abstract

Probiotics may represent a promising approach for reducingClostridioides(Clostridium)difficileinfections (CDIs). A clinical trial conducted by our group demonstrated that CDI patients undergoing adjunctive treatment withLactobacillusandBifidobacteriumprobiotics had a reduction in diarrheal duration and compositional changes in their stool microbiomes.

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Wolfe et al. (2019) studied this question.

synapsesocial.com/papers/6aaa5d2bac6343f54cdfe426 https://doi.org/10.1128/aac.00111-19

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Modified Mouse Model of Clostridioides difficile Infection as a Platform for Probiotic Efficacy Studies

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Modified Mouse Model of Clostridioides difficile Infection as a Platform for Probiotic Efficacy Studies

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